Useful Links & Tools
- MSDS
- Certificate of Analysis
- Celltransmissions 19(1) (143 KB )
- Bulk Quote
- Similar Products
D6790
Sigma
Defensin HNP-2 human
≥95% (HPLC)
| Synonym: | Neutrophil Peptide-2 |
| Amino Acid Sequence: | Cys-Tyr-Cys-Arg-Ile-Pro-Ala-Cys-Ile-Ala-Gly-Glu-Arg-Arg-Tyr-Gly-Thr-Cys-Ile-Tyr-Gln-Gly-Arg-Leu-Trp-Ala-Phe-Cys-Cys [Disulfide Bridges: 1−29, 3−18, 8−28] |
| CAS Number: | 99287-07-7 |
| Linear Formula: | C147H217N43O37S6 |
| Molecular Weight: | 3370.95 |
| MDL number: | MFCD00076222 |
Description
| Biochem/physiol Actions | This is an endogenous antibiotic peptide and monocyte chemotactic peptide produced by human neutrophils. Defensins are a family of 3-4 kDa (29-34 amino acids) peptides found in the granules of mammalian phagocytes. The members of this famuly are variably arginine-rich and all share 6 conserved cysteine residues that participate in intramolecular disulfide bonds. |
Properties
| assay | ≥95% (HPLC) |
| Gene Information | human ... DEFA1(1667) |
| storage temp. | −20°C |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| WGK Germany | 3 |
References
| reference | Selsted, M.E., and Harwig, S.S.L. Infect. Immun. 55, 2281, (1987) Abstract |
| Schroder J.M., and Harder, J., Human β-defensin-2. Int. J. Biochem. Cell Biol. 31, 645-651, (1998) | |
| Diamond G., and Bevins, C.L., β-Defensins: endogenous antibiotics of the innate host defense response. Clin. Immunol. Immunopathol. 88, 221-225, (1995) | |
| White S.H., et al., Structure, function, and membrane integration of defensins. Curr. Opin. Struct. Biol. 5, 521-527, (1995) Abstract |
